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¹ Central Institute of Brackish water Aquaculture (ICAR), 75, Santhome High Road, R. A. Puram, Chennai, India DOI : 10.4194/1303-2712-v14_4_05 Viewed : 4989 - Downloaded : 4382 Experiments in hapa and pond were carried out with antibiotic treated tiger shrimp, Penaeus monodon seeds to assess the morphological and hematological parameters during two different seasons viz, monsoon (March to August) and winter (October to February). Survival rates of the antibiotic treated seeds during transport were found to be significantly more compared to untreated control seeds. Average body weight (ABW), feed conversion ratio (FCR) and survival rate after 134 days of culture (DOC) showed no significant difference between antibiotic treated and untreated control seeds during both the seasons. On comparison of seasonal performance, the ABW was 25.79±2.29 g in monsoon and 13.53±2.23 g in winter batch with corresponding FCR of 1.62±0.03 and 2.57±0.01 and survival rate of 55.62±4.94 and 24.62±4.78 per cent respectively with significant difference. Total hemocyte count (THC), granular hemocyte (GH) and nongranular hemocyte (NGH) counts were not statistically significant between antibiotic treated and untreated animals. Significant difference was observed in water and soil quality parameters between seasons but not between antibiotic and control group experimental ponds. Keywords : Shrimp hematology, chloramphenicol, furazolidone, ciprofloxacin