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¹ Bingöl University, Department of Medical Services and Technics, Vocational School of Health Services, 12000 Bingöl, Turkey
² Inönü University, Faculty Fisheries, Malatya, Turkey
³ Bingöl University, Department of Crop and Animal Production, Genç Vocational School, 12000 Bingol, Turkey
⁴ Bingöl University, Department of Fisheries, Faculty of Agriculture 12000 Bingöl, Turkey DOI : 10.4194/1303-2712-v16_4_19 Viewed : 4505 - Downloaded : 3224 In this study, histopathological changes induced by lindane a gamma isomer of hexachlorocyclohexane and its intoxication associated with reproductive system and hormone levels were investigated in zebrafish. In all, 320 zebrafish adults approximately 1 year in age, (Danio rerio) obtained from a commercial entity were used in the study. Zebrafish were divided into 8 groups, each one containing 40 zebrafish.
Groups were organized as 0 (the control group), 1 ml/L methanol, and 5, 10, 20, 40, 80, 160 μg/L/day lindane. In the study, the gamma-HCH-isomer was applied at rates of 5/10/20/40/80/160 μg/L/day as doses of immersion to each group for 21 days. Macroscopically, the drop in egg production was observed, especially in the 80 and 160 μg/L/day groups of female zebrafish. A microscopic decrease in ovulation and biochemical decreases in estradiol (E2) levels (40/80/160 μg/L) were also observed in the female zebrafish. As a result, lindane was found to cause changes in the reproductive system, and consequently, to cause hormonal disorders and to have significant effects on ovulation and fertilization in the female zebrafish. Keywords : Zebrafish, ovulation, fertilization, histopathology