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¹ University of Agriculture, Department of Aquaculture and Fisheries Management, P.M.B. 2240, Abeokuta, Nigeria Viewed : 3915 - Downloaded : 12245 The effect of replacement of Soybean meal with dried poultry manure meal in the diets of Clarias gariepinus advanced fry was investigated. Six iso-nitrogenous diets containing 40% crude protein in which the soybean meal protein was replaced by dried poultry manure meal protein at 0% (diet PM1), 20% (diet PM2), 40% (diet PM3), 60% (diet PM4), 80% (diet PM5) and 100% (diet PM6) levels were formulated and fed to C. gariepinus advanced fry of average weight of 0.35g for 8 weeks in adapted aquaria. At the end of the trial, weight gain of 1.35 g was the highest in fish fed diets PM1 and PM4. Feed conversion ratio (FCR) of 1.89 was the lowest in fish fed diet PM3 but not significantly different (P>0.05) from 1.90 of fish fed diets PM1 and PM4. Net protein utilization (NPU) was the highest in fish fed diet PM1 with a value of 39.35% and the lowest with a significant difference (P<0.05) in fish fed diet PM6 with a value of 34.26%. Percentage survival value of 87% in fish fed diet PMI was significantly the higher (P<0.05) than 80% of fish fed diets PM2,3 and 4 and the lowest in fish fed diets PM5 and PM6 with an equal value of 60% respectively. In view of the above, it is evident that dried poultry manure meal can replace up to 60% of soybean meal in the diets of C. gariepinus advanced fry. Keywords : adapted aquaria, feed intake, feed conversion ratio, significant difference