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¹ Faculty of Fisheries, Sher-e-Kashmir University of Agricultural Science and Technology, Kashmir, J&K, India Viewed : 4296 - Downloaded : 6324 In order to determine the immunomodulatory effect of dietary intake of levamisole in the common carp, specimen were fed diets containing 0 (control), 125, 250 and 500 mg levamisole kg^-1 of dry diet for a period of 70 days. Experimental stock was challenged intra-peritoneally with Aeromonas hydrophila on 30^th and 58^th day. Hematobiochemical parameters were determined on day 0, 57 and day 70. The total erythrocyte count, haemoglobin content, hematocrit value, total serum protein, albumin and globulin content were significantly (P<0.05) enhanced in levamisole supplemented groups particularly in 250 mg kg^-1 group; however the TLC was significantly (P<0.05) higher in control (infected) group. Lysozyme activity and NBT assay were significantly stimulated in levamisole supplemented groups displaying the highest value in 250 mg kg^-1 group on day 57. After the stock in all the groups had been challenged intra-peritoneally with Aeromonas hydrophila on 30^th and 58^th day, the relative percentage survival was significantly higher in 250 mg kg^-1 group (89.6%), followed by 500 mg kg^-1 group (81.3%) and 100 mg kg^-1 group (47.9%). Specific growth rate (SGR) was significantly (P<0.05) the highest in 250 mg kg^-1 group (2.67%) and the lowest in control group (1.82%) and feed conversion ratio (FCR) value was found to be the best in 250 mg kg^-1 group (1.81), followed by 500 mg kg^-1 group (1.85), 100 mg kg^-1 group (2.02) and control group (2.32). The findings of the present investigation suggest that the incorporation of levamisole in the diet of common carp fingerlings certainly enhances the non-specific immunity, increases their resistance to infection, and reduces the mortality and enhances the growth of fish. Keywords : hematobiochemical parameters, nitroblue tetrazolium assay, lysozyme activity, growth, Aeromonas hydrophila; Cyprinus carpio