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¹ Vinoba Bhave University, S.S.L.N.T Mahila College, Department of Zoology, Dhanbad-826001, Hazaribagh India
² Barkatullah University, Department of Bioscience, Endocrinology Lab, Bhopal-462026 India DOI : 10.4194/trjfas.2011.0104 Viewed : 4197 - Downloaded : 4526 45 fishes Cirrhinus mrigala weighin g 55±10 g were div ided into 3 group s of fifteen each. Group 1st received fish diet only and served as control, while group 2nd exposed with bisphenol-A (BPA) (2 mg/L) and group 3rd exposed with vitamin-C (50 mg/L) and BPA (2 mg/L) for 15, 30 and 60 days and histopathological studies were observed in their liver and kidney. Bisphenol-A showed degenerative changes in hepatic and renal cells after 15 days exposures. However, these changes were more prominent and severe in later part i.e. 30 and 60 of the experiments. The animals exposed with BPA for 30 and 60 days showed atrophied changes in uriniferous tubules and hypertrophied hepatic nuclei, necrosis in hepatocytes and interrenal cells as compared to control group. The animals exposed with vitamin-C along with BPA showed recovery in their hepatic cells, interrenal cells, and uriniferous tubules after 15, 30 and 60 days as compared to BPA groups. These observations denotes that vitamin-C i.e. antioxidant has some antidote role or protective action against bisphenol-A toxicity in Cirrhinus mrigala. Keywords : Liver, kidney, histopathology, Cirrhinus mrigala