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¹ University of Benin, Department of Animal and Environmental Biology (AEB), Benin, Nigeria
² Western Delta University, Department of Environmental Science, Oghara Delta State, Nigeria DOI : 10.4194/1303-2712-v11_3_21 Viewed : 4130 - Downloaded : 3346 The adult crowned bullfrog, Hoplobatrachus occipitalis was exposed to 0.25, 0.50, 1.00 and 2.00 mg/L cadmium for 28 days. The effect of cadmium on selected biochemical parameters- superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) in the liver were tested. Biochemical observations revealed significant (P<0.05) dose-dependent increase in the specific activity of superoxide dismutase (SOD) and catalase (CAT) relative to controls. This could be due to increased production of these antioxidants to counteract oxidative stress and lipid peroxidation induced by cadmium. Glutathione (GSH) level decreased with increase in the concentration of heavy metal. Thiobarbituric acid reactive substances (TBARS) which is an index of lipid peroxidation increased as concentration of cadmium increased. The increased level of TBARS in the liver of cadmium exposed frogs is an indication of increased membrane lipid peroxidation which could lead to cell damage. Keywords : Cadmium, Hoplobatrachus occipitalis, liver, biochemical parameters