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¹ Faculty of Marine Sciences and Technology, Mustafa Kemal University, 31200, Hatay, Turkey DOI : 10.4194/1303-2712-v13_2_02 Viewed : 4450 - Downloaded : 4230 Metal levels (Cd, Cr, Cu, Fe, Mn, Pb and Zn) in the gill, hepatopancreas, ovary, testis and mantle of male and female cuttlefish Sepia officinalis in İskenderun Bay were investigated. All elements differ in accumulation in tissues and sex significantly (p<0.05). Concentrations of Cd in the tissues of male and female cuttlefish samples ranged between 0.12-34.7 mg/kg. Cr levels in tissues of males and females ranged between 0.59-1.26 mg/kg. Cu concentrations in all tissues were found and ranged between 8.83 and 1296 mg/kg. Fe concentrations in the mantle of female and male samples were found 0.35 and 0.36 mg/kg, respectively. Pb concentrations in the mantles of female and male samples were found between 1.74-1.79 mg/kg. The highest Zn concentrations in hepatopancreas of male and female samples were found 181 mg/kg and 272 mg/kg respectively (P<0.05). In the mantle tissue of S. officinalis, metal levels independent of sex were in the following order: Cu>Zn>Cd>Pb>Cr>Mn>Fe. In accordance with limit values, the present study found out that the mantle tissue of cuttlefish, S. officinalis, was overlimited with Cd and Pb Keywords : Cuttlefish, Sepia officinalis, sex, heavy metals, risk evaluation