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¹ Annamalai University, Faculty of Marine Sciences, Centre of Advanced Study in Marine Biology, Parangipettai 608502, Tamil Nadu, India DOI : 10.4194/1303-2712-v13_3_01 Viewed : 4716 - Downloaded : 4217 This study was conducted to assess the role of dietary commercial brewer's yeast, Saccharomyces cerevisiae on the growth factors (final weight, specific growth rate (SGR) and feed conversion ratio (FCR)), survival rate, haematological parameters and serum metabolic products (glucose and total protein) of the clown fish, Amphiprion percula. Feeding trial was carried out for 90 days to study the effect of brewer’s yeast on the young ones of clown fish, A. percula. Fifty young ones (avg. wt 1.345±0.03 g) were randomly distributed in each treatment and fed with different diets, prepared with six incremental levels (0%, 0.5%, 1%, 2%, 3%, and 5% of the feed) of brewer’s yeast except the control. Haematology and serum parameters were studied before pathogen challenge and they were significantly higher (P<0.05) in 2% yeast supplemented group. Survival (%) of the fish, after challenging with Streptococcus sp., was also higher in the yeast fed groups. Results of our shortrange study give an idea about the role of yeast in marine ornamental aquaculture. Keywords : Clownfish, Amphiprion percula, growth performance, fish pathogen, challenging study