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¹ Ondokuz Mayıs University, Faculty of Veterinary Medicine, Department of Biochemistry, Samsun (55270) / Türkiye DOI : 10.4194/TRJFAS26120 Viewed : 225 - Downloaded : 153 In this study, the antioxidant effects and the free radical scavenging capacity of quercetin were investigated in IPNV-infected Rainbow Trout Gonad-2 (RTG-2) continuous cell culture. For this purpose, four different groups were formed (Control, IPNV, Quercetin, IPNV+Quercetin). Malondialdehyde (MDA), Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Ceruloplasmin (Cp), and Glutathione Peroxidase (GPx) activities were measured at 0, 24, 48, 72, and 96 hours. According to the results of our study, there was a significant increase in TAS, TOS, and Cp results in the groups containing IPNV-infected cells. According to TAS and TOS measurements, there was a statistically significant increase both between groups and at different hours. When GPx results were analyzed, it was observed that there was no statistically significant change between the groups and between the measurement hours. When the MDA results were analyzed, it was observed that there was no change in the measurements made at different hours, while there were significant differences between the groups. It was observed that quercetin can minimize the damage caused by scavenging free radicals in the environment and thus provides an important development for fish farming and economy in cells infected with IPNV in the laboratory environment. Keywords : IPNV Quercetin Rainbow trout (Oncorhynchus mykiss) Oxidative stress